Gian Paolo Accotto


Presently the main interest is in understanding the response of plants to viral infections. The model plant is tomato, and the viruses are TSWV and TYLCSV. Modifications in plant gene expression is analysed using microarrays, qRT-PCR, siRNA-seq, as well as bioinformatics.
The impact of symbiotic interaction between tomato and mycorrhizal fungi on the establishment of virus infection is also investigated, with the aim to define if mycorrhization plays a beneficial role in this plant/pathogen interaction or not. This is analysed using transcriptomics as well as by studying phytohormone regulation.
Recently, recombinant molecules between the two Begomovirus species TYLCSV and TYLCV were characterized from tomato samples collected in Sicily, highlighting the plasticity of geminivirus genomes.
Another field of interest is virus resistance, either by genetic modification of the plant genome (transgenic plants), or using naturally occurring genes (classical breeding), targetting TYLCSV and TSWV. An antiviral strategy against geminiviruses was patented.




  • 2014 - Transcriptomics of the Interaction between the Monopartite Phloem-Limited Geminivirus Tomato Yellow Leaf Curl Sardinia Virus and Solanum lycopersicum Highlights a Role for Plant Hormones, Autophagy and Plant Immune System Fine Tuning during Infection. - Miozzi L., Napoli C., Sardo L., Accotto G.P. - PLoS One, 9: e89951
  • 2013 - From immunity to susceptibility: Virus resistance induced in tomato by a silenced transgene is lost as TGS overcomes PTGS - Catoni, M., Lucioli, A., Doblas-Ibáñez, P., Accotto, G.P., Vaira, A.M. - Plant journal, 75:941-953
  • 2013 - Analysis of small RNAs derived from tomato yellow leaf curl Sardinia virus reveals a cross reaction between the major viral hotspot and the plant host genome - Miozzi L., Pantaleo V., Burgyán J., Accotto G.P., Noris E. - Virus Research, 178:287-296
  • 2013 - The arbuscular mycorrhizal symbiosis attenuates symptom severity and reduces virus concentration in tomato infected by Tomato yellow leaf curl Sardinia virus (TYLCSV) - Maffei G, Miozzi L, Fiorilli V, Novero M, Lanfranco L, Accotto GP. - Mycorrhiza,
  • 2012 - Recombination profiles between Tomato yellow leaf curl virus and Tomato yellow leaf curl Sardinia virus in laboratory and field conditions: evolutionary and taxonomic implications - Davino, S., Miozzi L., Panno, S., Rubio, L., Davino, M., Accotto, G.P. - Journal of general virology, 2712-2717
  • 2012 - The unconventional geminivirus Beet curly top Iran virus: satisfying Koch’s postulates and determining vector and host range - Soleimani, R., Matic, S., Taheri, H., Behjatnia S.A.A., Vecchiati, M., Izadpanah, K & Accotto, G.P. - Annals of Applied Biology, 174–181
  • 2011 - An Rgg Sequence In The Replication-associated Protein (rep) Of Tomato Yellow Leaf Curl Sardinia Virus Is Involved In Transcriptional Repression And Severely Impacts Resistance In Rep-expressing Plants - Sardo L., Lucioli A., Tavazza M., Masenga V., Tavazza R., Accotto G.P., Noris E. - Journal Of General Virology (54890J0), volume 92 pag. 204-209
  • 2011 - RNA Viruses And Their Silencing Suppressors Boost Abutilon Mosaic Virus, But Not The Old World Tomato Yellow Leaf Curl Sardinia Virus. - Sardo L., Wege C., Kober S., Kocher C., Accotto G.P., Noris E. - Virus Research (06153J0), volume 161 pag. 170-180
  • 2011 - Arbuscular Mycorrhizal Symbiosis Limits Foliar Transcriptional Responses To Viral Infection And Favors Long-term Virus Accumulation - Miozzi L., Catoni M. Fiorilli V., Mullineaux P.M. , Accotto G.P., Lanfranco L. - Molecular Plant-microbe Interactions (09067J0), volume 24 pag. 1562-1572
  • 2010 - Introgression Of Resistance To Two Mediterranean Virus Species Causing Tomato Yellow Leaf Curl Into A Valuable Traditional Tomato Variety. - Barbieri M., Acciarri N., Sabatini E., Sardo L., Accotto G.P., Pecchioni N. - Journal Of Plant Pathology (00077NN), volume 92 pag. 485-493
  • 2010 - Transovarial Transmission Of Begomoviruses In Bemisia Tabaci - Accotto G.P., Sardo L. - P.a. Stansly, S.e. Naranjo, Bemisia: Bionomics And Management Of A Global Pest (eds.), Publisher: Springer Science+Business Media B.V.
  • 2010 - The Complete Nucleotide Sequence Of An Isolate Of Tomato Yellow Leaf Curl Sardinia Virus Found In Sicily - Davino S., Miozzi L., Accotto G.P. - Archives Of Virology (15471J0), volume 155 pag. 1539-1542
  • 2010 - Ortom: A Multi-species Approach Based On Conserved Co-expression To Identify Putative Functional Relationships Among Genes In Tomato. - Miozzi L., Provero P., Accotto G.P. - Plant Molecular Biology (05842J0), volume 73 pag. 519-532
  • 2009 - Comparative Analysis Of Expression Profiles In Shoots And Roots Of Tomato Systemically Infected By Tomato Spotted Wilt Virus Reveals Organ-specific Transcriptional Responses - Catoni M., Miozzi L., Fiorilli V., Lanfranco L., Accotto G.P. - Molecular Plant-microbe Interactions (09067J0), volume 22 pag. 1504-1513
  • 2009 - Global And Cell-type Gene Expression Profiles In Tomato Plants Colonized By An Arbuscular Mycorrhyzal Fungus. - Fiorilli V., Catoni M., Miozzi L., Novero M., Accotto G.P., Lanfranco L. - New Phytologist (71720J0), volume 184 pag. 975-987
  • 2009 - Two New Natural Begomovirus Recombinants Associated With The Tomato Yellow Leaf Curl Disease Co-exist With Parental Viruses In Tomato Epidemics In Italy - Davino S., Napoli C., Dellacroce C., Miozzi L., Noris E., Davino M., Accotto G.P. - Virus Research (06153J0), volume 143 pag. 15-23
  • 2008 - A Single-tube Pcr Assay For The Detecting Viruses And Their Recombinants That Cause Tomato Yellow Leaf Curl Disease In The Mediterranean Basin. - Davino D., Davino M., Accotto G.P. - Journal Of Virological Methods (03232J0), volume 147 pag. 93-98
  • 2008 - Real-time Pcr For The Quantitation Of Tomato Yellow Leaf Curl Sardinia Virus In Tomato Plants And In Bemisia Tabaci. - Mason, G., Caciagli, P., Accotto, G.p., Noris, E., - Journal Of Virological Methods (03232J0), volume 147 pag. 282-289
  • 2008 - Basil (ocimum Basilicum) A New Host Of Pepino Mosaic Virus. - Davino, S., Accotto, G.p., Masenga, V., Torta, L., Davino, M. - New Disease Report , volume 18 pag. x-x
  • 2008 - Potentiality Of Methylation-sensitive Amplification Polymorphism (msap) In Identifying Genes Involved In Tomato Response To Tomato Yellow Leaf Curl Sardinia Virus - Mason, G., Noris, E., Lanteri, S., Acquadro, A., Accotto, G.p., Portis, E. - Plant Molecular Biology Reporter (11449J0), volume 26 pag. 156-173
  • 2008 - Ourmiavirus - Accotto, G.p., Milne, R.g. - Encyclopedia Of Virology, 5 Vols.. Oxford: Elsevier. P.500-501 (B.W.J. Mahy and M.H.V. Van Regenmortel, Editors), Publisher: Elsevier
  • 2007 - Founder Effect, Plant Host And Recombination Shape The Emergent Population Of Begomoviruses That Cause The Tomato Yellow Leaf Curl Disease In The Mediterranean Basin. - (1)garcia-andres, S., Accotto, G.p.,(1) Navas-castillo, J. & (1)moriones, E. - Virology (95304J0), volume 359 pag. 302-312
  • 2007 - Detection Methods For Tylcv And Tylcsv - Accotto, G.p., Noris, E. - Tomato Yellow Leaf Curl Virus Disease. Management, Molecular Biology, Breeding For Resistance. Editor H. Czosnek , Publisher: Springer
  • 2006 - Spread Of Tomato Yellow Leaf Curl Virus In Sicily: Partial Displacement Of Another Geminivirus Originally Present. - Davino, S., Napoli, C., Davino, M. & Accotto, G.p. - European Journal Of Plant Pathology (10845J0), volume 114 pag. 293-299
  • 2005 - Prima Segnalazione Del Virus Dell’accartocciamento Fogliare Giallo Del Pomodoro (tylcv) In Sardegna. - Nannini, M., Testa, M., Napoli, C., Accotto, G.p. - Informatore Fitopatologico , volume 55 pag. 53-54
  • 2005 - Flexiviridae. - Adams, M.j., Accotto, G,p., Agranovsky, A.a., Bar-joseph, M., Boscia, D., Brunt, A.a., Candresse, T., Coutts, R.h.a., Dolja, V.v., Falk, B.w., Foster, G.d., Gonsalves, D., Jelkmann, W., Karasev, A., Martelli, G.p., Mawassi, M., Milne, R.g., Minafra, A. - In:virus Taxonomy, Viiith Report Of The Ictv, C.m.fauquet, M.a. Mayo, J. Maniloff, U. Desselberger & L.a. Ball, Eds , Publisher: Elsevier/Academic Press
  • 2005 - Genus Ophiovirus - Vaira, A.m., Accotto, G.p. Gago-zachert, S., Garcia, M.l., Grau, O., Milne, R.g., Morikawa, T., Natsuaki, T., Torok, V., Verbeek, M. & Vetten, H.j. - In: Virus Taxonony: Viiith Report Of The International Committee On Taxonomy Of Viruses”. Pp. 673-679 , Publisher: Elsevier Academic Press
  • 2005 - Field Evaluation Of Tomato Hybrids Engineered With Tomato Spotted Wilt Virus Sequences For Virus Resistance, Agronomic Performance, And Pollen-mediated Transgene Flow. - Accotto, G.p., Nervo, G., Acciarri, N., Tavella, L., Vecchiati, M., Schiavi, M., Mason, G. & Vaira, A.m. - Phytopathology (77147J0), volume 95 pag. 800-807
  • 2004 - Tomato Yellow Leaf Curl Sardinia Virus Can Overcome Transgene-mediated Rna Silencing Of Two Essential Viral Genes. - Noris, E., Lucioli, A., Tavazza, R., Caciagli, P., Accotto, G.p. , And Tavazza, M. - Journal Of General Virology (54890J0), volume 85 pag. 1745-1749
  • 2004 - Gravi Malattie Da Virus Minacciano Le Coltivazioni Di Pomodoro In Serra. - Davino, S., Accotto, G.p., Vaira, A.m., Davino, M. - Informatore Fitopatologico , volume 6 pag. 35-40
  • 2004 - Proteomics As A Tool To Improve Investigation Of Substantial Equivalence In Genetically Modified Organisms: The Case Of A Virus-resistant Tomato. - Corpillo, D., Gardini, G., Vaira, A.m.,basso, M., Aime, S., Accotto, G.p. & Fasano, M. - Proteomics (13608J0), volume 4 pag. 193-200
  • 2004 - Tylcsv Dna, But Not Infectivity, Can Be Transovarially Inherited By The Progeny Of The Whitefly Vector Bemisia Tabaci (gennadius) - Bosco, D., Mason, G.& Accotto, G.p. - Virology (95304J0), volume 323 pag. 276-283
  • 2004 - Evidence For A Direct Link Between Glutathiione Biosynthesis And Stress Defense Gene Expression - L. Ball,a G.p. Accotto,b U. Bechtold,c G. Creissen,a D. Funck,d A. Jimenez,e, B. Kular, A, N. Leyland, A J. Mejia-carranza, A, H. Reynolds, A, S.karpinski & P.m.mullineaux - Plant Cell (09000J0), volume 16 pag. 2448-2462
  • 2004 - Organismi Naturalmente Modificati. Ricombinazioni Genetiche Dei Vegetali: Una Storia Vecchia Quanto L’uomo. - Accotto, G.p. - Cluster , volume 4 pag. 164-165
  • 2003 - Amarilleos En Los Cultivos De Tomate Asociados A Tomato Chlorosis Virus (tocv) Y Tomato Infectious Chlorosis Virus (ticv) En Espana . - Font M.i., Vaira A.m. , Accotto G.p., Lacasa A., Serra J., Gomila J., Juarez M., Espino A I., Jorda M.c. - Bol. San. Veg. Plagas , volume 29 pag. 109-121
  • 2003 - Tomato Yellow Leaf Curl Sardinia Virus Rep-derived Resistance To Homologous And Heterologous Geminiviruses Occurs By Different Mechanisms And Is Overcome If Virus-mediated Transgene Silencing Is Activated. - Lucioli A.1, Noris E.2, Brunetti A.3, Tavazza R.4, Ruzza V.5, Castillo A.g. 6, Bejarano E.r. 7, Accotto G.p. 8,tavazza M. 9. - Journal Of Virology (62788J0), volume 77 pag. 6785-6798
  • 2003 - An Isolate Of Apple Stem Groving Virus Associated With Cleopatra Mandarin Fruit Intumescence. - Lovisolo O., Accotto G P., Masenga V., Colariccio A., - Fitopatologia Brasileira , volume 28 pag. 54-58
  • 2003 - Characterization Of Two Tomato Lines Highly Resistant To Tomato Spotted Wilt Virus Following Transformation With The Viral Nucleoprotein Gene. - Nervo G., Cirillo C., Accotto G.p., Vaira A.m. - Journal Of Plant Pathology (00077NN), volume 85 pag. 139-144
  • 2003 - The Partial Sequence Of Rna 1 Of The Ophiovirus Ranunculus White Mottle Virus Indicates Its Relationship To Rhabdoviruses And Provides Candidate Primers For An Ophiovirus-specificrt+pcr Test. - Vaira A.m. 1, Accotto G.p. 2, Costantini A. 3, Milne R.g. 4. - Archives Of Virology (15471J0), volume 148 pag. 1037-1050
  • 2003 - First Report Of Tomato Yellow Leaf Curl Virus (tylcv) In Italy. - Accotto G.p. , Bragaloni M. , Luisoni E. , Davino D. , Davino M. - Plant Pathology (77264J0), Publisher: 52
  • 2002 - Nucleotide Sequence Genome Organization And Phylogenetic Analisys Of Indian Citrus Ringspot Virus - Rustici G., Milne Rg., Accotto Gp. - Archives Of Virology (15471J0), volume 147 pag. 2215-2224
  • 2002 - First Report Of Tomato Infectious Chlorosis Virus In Spain - Font M.i., Martinez-culebras P., Jorda M.c., Louro D., Vaira A.m., Accotto G.P. - Plant Disease (01997J0), 86: 696
  • 2002 - Molecular Diagnosis Of Ranunculus White Mottle Virus In Two Ornamental Species. - Vaira A.M, Accotto G.P., Lisa V., Vecchiati M., Masenga V. - Acta Horticulturae , 568: 29-33
  • 2002 - Tomato Infectious Chlorosis Virus Caused Leaf Yellowing And Reddening Of Tomato In Italy - Vaira Am., Accotto Gp., Vecchiati M., Bragaloni M. - Phytoparasitica (77140J0), volume 30 pag. 290-294
  • 2001 - Transgenically Expressed T-rep Of Tomato Yellow Leaf Curl Sardinia Virus Acts As A Trans-dominant-negative Mutant, Inhibiting Viral Transcription And Replication - Brunetti A.1, Tavazza R. 2, Noris E. 3, Lucioli A. 4, Accotto G P. 5, Tavazza M. 6 - Journal Of Virology (62788J0), volume 75 pag. 10573-10581